The Chiesa della Madonna dell'Orto, considered to be the most beautiful Gothic church in Venice, was originally constructed in the 14th century by the Humiliati and later completed in the 15th century. It gained prominence not only for its stunning Gothic architecture but also as the parish church of Tintoretto, who created many artworks for its interior and was ultimately buried there.

The Chiostro was also built by the Humiliati. Like many monastic complexes, it originally served as a space for contemplation and community life. Built in conjunction with the church, it was later taken over by the Canons Regular of San Giorgio in Alga.

When, in 1797, general Napoleone Bonaparte crowned himself King of Italy, he disbanded and suppressed many of the religious orders in Venice whose properties were sold to private citizens. The cloister and what was left of the ancient monastery of Madonna dell'Orto was sold to the Gelmi di Caporiacco, which restored it and still owns it to this day.

The Chiostro is often appreciated for its historical significance and serene beauty, complementing the church’s rich artistic heritage.